Program
Scientific Program (São Carlos, September 28-30, 2014)
28.09.2014
15:00-19:00 Registration
19:00-19:15 Opening remarks
19:15-20:00 Opening Lecture
Michael N.G. James (University of Alberta, Edmonton/Canada)
What can Avian Ovomucoids teach us about Serine Peptidase Specificity?
29.09.2014
8:30-12:00 Morning Session
Proteases in diseases and as drug targets
8:30-9:10 Dieter Brömme (University of British Columbia Vancouver/Canada)
From protease mechanisms to mechanism-based inhibitors
9:10-9:40 Maria Luiza Vilela Oliva (UNIFESP, São Paulo/Brazil)
Regulation of cellular signaling in the human diseases by using plant protease inhibitor
9:40-10:10 Thomas Reinheckel (Albert-Ludwigs University Freiburg/Germany)
Genetic analysis of lysosomal proteases in mouse models of human cancers
10:10-10:30 Student presentation – To be selected
Coffee break
10:50:11:20 Robert A. Lazarus (Genentech, South San Franciso/USA)
Noncanonical Modulators of BACE1 Activity for Alzheimer’s Disease
11:20-11:40 Rodrigo Luiz O.R. Cunha
Title – To be announced
11:40-12:00 Student presentation – To be selected
Lunch break
14:00-18:00 Afternoon Session
Chemistry of novel inhibitors and substrates
14:00-14:40 Tanja Schirmeister (University of Mainz, Germany)
Tuning the reactivity and affinity of protease inhibitors
14:40-15:10 Luiz Juliano Neto (UNIFESP, São Paulo/Brazil)
Interface studies of cancer with the hydrolytic activities and inhibition of Kallikrein Related Peptidases (KLKs)
15:10-15:30 Student presentation – To be selected
15:30-15:50 Student presentation – To be selected
Coffee break
16:20-16:50 Matthew Bogyo (Stanford University, California/USA)
Using small molecules to study protease function: applications to parasites, cancer and inflammation
16:50-17:20 Arlene Gonçalves Correa (UFSCAR, São Carlos/Brazil)
Synthesis of Natural Product and Analogs as Inhibitors of Cysteine Proteases
17:20-17:40 Student presentation – To be selected
17:40-18:00 Student presentation – To be selected
18:00-19:30 Poster Session
30.09.2014
8:30-12:00 Morning Session
Proteases and infectious diseases
8:30-9:10 Connor Caffrey (University of California San Francisco, California/USA)
Targeting orthologous proteases for anti-parasite chemotherapy
9:10-9:40 Francois Jean (University of British Columbia Vancouver/Canada)
Human site-1-protease/SKI-1: An emerging host-cell target for anti-dengue drug discovery
9:40-10:00 Ana Paula Cabral de Araújo Lima (UFRJ, Rio de Janeiro/Brazil)
Natural protease inhibitors in pathogenic protozoa
10:00-10:20 Student presentation – to be selected
Coffee break
10:50:11:20 Rafael Victorio Carvalho Guido (USP, São Carlos/Brazil)
Structural Biology and Medicinal Chemistry Approaches Toward the Discovery of New Bioactive Compounds: Applications in Infectious Diseases
11:20-11:40 Carlos Alberto Montanari (USP, São Carlos/Brazil)
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and in vitro Assay
11:40-12:00 Student presentation – To be selected
Lunch break
14:00-18:00 Afternoon Session
Natural product and endogenous protease inhibitors
14:00-14:40 Vanderlan da Silva Bolzani (UNESP, Araraquara/Brazil)
Peptides from Violaceae plant species, Discovering New Biologically Active Compounds from Brazilian Biodiversity
14:40-15:10 Luciano Puzer (UFABC, São Paulo/Brazil)
Development of Inhibitors for Human Tissue Kallikreins 5 and 7 (KLK5 AND KLK7)
15:10-15:30 Student presentation – To be selected
15:30-15:50 Student presentation – To be selected
Coffee break
16:20-16:50 Quezia Bezerra Cass (UFSCar, São Carlos/Brazil)
New models of protein ligand screening
16:50-17:30 Maurício Marques, Ph.D.
Advanced biopharmaceuticals analysis using HPLC-Chip/MS technology
17:30-17:50 Richele Priscila Severino (UFG, Catalão/Brazil)
Natural products as novel cathepsin inhibitors
Break
20:00-23:00 Farewell Dinner
